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Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human - Nature Genetics

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Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human - Nature Genetics

Functional studies of long noncoding RNAs (lncRNAs) have been hindered by the lack of methods to assess their evolution. Here we present lncRNA Homology Explorer (lncHOME), a computational pipeline that identifies a unique class of long noncoding RNAs (lncRNAs) with conserved genomic locations and patterns of RNA-binding protein (RBP) binding sites (coPARSE-lncRNAs). Remarkably, several hundred human coPARSE-lncRNAs can be evolutionarily traced to zebrafish.

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Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human - Nature Genetics

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Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human - Nature Genetics

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