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Breaking NGF–TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection - Nature Immunology

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Breaking NGF–TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection - Nature Immunology

Melanoma cells, deriving from neuroectodermal melanocytes, may exploit the nervous system's immune privilege for growth. Here we show that nerve growth factor (NGF) has both melanoma cell intrinsic and extrinsic immunosuppressive functions. Autocrine NGF engages tropomyosin receptor kinase A (TrkA) on melanoma cells to desensitize interferon γ signaling, leading to T and natural killer cell exclusion.

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Breaking NGF–TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection - Nature Immunology

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Breaking NGF–TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection - Nature Immunology

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