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4 months ago

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Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens - npj Antimicrobials and Resistance

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Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens - npj Antimicrobials and Resistance

Emerging resistance to all available antibiotics highlights the need to develop new antibiotics with novel mechanisms of action. Most of the currently used antibiotics target Gram-positive bacteria while Gram-negative bacteria easily bypass the action of most drug molecules because of their unique outer membrane. This additional layer acts as a potent barrier restricting the entry of compounds into the cell.

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Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens - npj Antimicrobials and Resistance

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Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens - npj Antimicrobials and Resistance

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