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The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center - Nature Chemical Biology

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The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center - Nature Chemical Biology

Translation termination is an essential cellular process, which is also of therapeutic interest for diseases that manifest from premature stop codons. In eukaryotes, translation termination requires eRF1, which recognizes stop codons, catalyzes the release of nascent proteins from ribosomes and facilitates ribosome recycling. The small molecule SRI-41315 triggers eRF1 degradation and enhances translational readthrough of premature stop codons.

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The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center - Nature Chemical Biology

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The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center - Nature Chemical Biology

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