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Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR - Nature Biotechnology

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Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR - Nature Biotechnology

The ability to control gene expression in mammalian cells is crucial for safe and efficacious gene therapies and for elucidating gene functions. Current gene regulation systems have limitations such as harmful immune responses or low efficiency. We describe the pA regulator, an RNA-based switch that controls mammalian gene expression through modulation of a synthetic polyA signal (PAS) cleavage introduced into the 5′ UTR of a transgene.

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Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR - Nature Biotechnology

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Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR - Nature Biotechnology

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