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Extracellular targeted protein degradation: an emerging modality for drug discovery - Nature Reviews Drug Discovery

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Extracellular targeted protein degradation: an emerging modality for drug discovery - Nature Reviews Drug Discovery

Targeted protein degradation (TPD) has emerged in the past decade as a major new drug modality to remove intracellular proteins with bispecific small molecules that recruit the protein of interest (POI) to an E3 ligase for degradation in the proteasome. Unlike classic occupancy-based drugs, intracellular TPD (iTPD) eliminates the target and works catalytically, and so can be more effective and sustained, with lower dose requirements.

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Extracellular targeted protein degradation: an emerging modality for drug discovery - Nature Reviews Drug Discovery

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Extracellular targeted protein degradation: an emerging modality for drug discovery - Nature Reviews Drug Discovery

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