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Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis - Cell Death & Differentiation

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Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis - Cell Death & Differentiation

Lipid droplet (LD) accumulation is a notable feature of obesity-induced cardiomyopathy, while underlying mechanism remains poorly understood. Here we show that mice fed with high-fat diet (HFD) exhibited significantly increase in cardiac LD and RTN3 expression, accompanied by cardiac function impairment. Multiple loss- and gain-of function experiments indicate that RTN3 is critical to HFD-induced cardiac LD accumulation.

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Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis - Cell Death & Differentiation

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Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis - Cell Death & Differentiation

Rate This Post

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Unlocking the Power of Knowledge for Humanity's Progress

Unlocking the Power of Knowledge
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Unlocking the Power of Knowledge
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