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Spatiotemporal characterization of glial cell activation in an Alzheimer's disease model by spatially resolved transcriptomics - Experimental & Molecular Medicine

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Spatiotemporal characterization of glial cell activation in an Alzheimer's disease model by spatially resolved transcriptomics - Experimental & Molecular Medicine

The molecular changes that occur with the progression of Alzheimer's disease (AD) are well known, but an understanding of the spatiotemporal heterogeneity of changes in the brain is lacking. Here, we investigated the spatially resolved transcriptome in a 5XFAD AD model at different ages to understand regional changes at the molecular level. Spatially resolved transcriptomic data were obtained from 5XFAD AD models and age-matched control mice.

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Spatiotemporal characterization of glial cell activation in an Alzheimer's disease model by spatially resolved transcriptomics - Experimental & Molecular Medicine

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Spatiotemporal characterization of glial cell activation in an Alzheimer's disease model by spatially resolved transcriptomics - Experimental & Molecular Medicine

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for Humanity's Progress