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Mitochondrial regulation of GPX4 inhibition–mediated ferroptosis in acute myeloid leukemia - Leukemia

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Mitochondrial regulation of GPX4 inhibition–mediated ferroptosis in acute myeloid leukemia - Leukemia

Resistance to apoptosis in acute myeloid leukemia (AML) cells causes refractory or relapsed disease, associated with dismal clinical outcomes. Ferroptosis, a mode of non-apoptotic cell death triggered by iron-dependent lipid peroxidation, has been investigated as potential therapeutic modality against therapy-resistant cancers, but our knowledge of its role in AML is limited. We investigated ferroptosis in AML cells and identified its mitochondrial regulation as a therapeutic vulnerability.

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Mitochondrial regulation of GPX4 inhibition–mediated ferroptosis in acute myeloid leukemia - Leukemia

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