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Targeting hypoxia-inducible factors: therapeutic opportunities and challenges - Nature Reviews Drug Discovery

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Targeting hypoxia-inducible factors: therapeutic opportunities and challenges - Nature Reviews Drug Discovery

Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for adaptation of metazoans to limited oxygen availability. Recently, HIF activation and inhibition have emerged as therapeutic targets in various human diseases. Pharmacologically desirable effects of HIF activation include erythropoiesis stimulation, cellular metabolism optimization during hypoxia and adaptive responses during ischaemia and inflammation.

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Targeting hypoxia-inducible factors: therapeutic opportunities and challenges - Nature Reviews Drug Discovery

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Targeting hypoxia-inducible factors: therapeutic opportunities and challenges - Nature Reviews Drug Discovery

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