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Pituitary stem cells: past, present and future perspectives - Nature Reviews Endocrinology

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Pituitary stem cells: past, present and future perspectives - Nature Reviews Endocrinology

Pituitary cells that express the transcription factor SOX2 are stem cells because they can self-renew and differentiate into multiple pituitary hormone-producing cell types as organoids. Wounding and physiological challenges can activate pituitary stem cells, but cell numbers are not fully restored, and the ability to mobilize stem cells decreases with increasing age. The basis of these limitations is still unknown.

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Pituitary stem cells: past, present and future perspectives - Nature Reviews Endocrinology

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Pituitary stem cells: past, present and future perspectives - Nature Reviews Endocrinology

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