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Associating CYP2A6 structural variants with ovarian and lung cancer risk in the UK Biobank: replication and extension - European Journal of Human Genetics

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Associating CYP2A6 structural variants with ovarian and lung cancer risk in the UK Biobank: replication and extension - European Journal of Human Genetics

CYP2A6 is a polymorphic enzyme that inactivates nicotine; structural variants (SVs) include gene deletions and hybrids with the neighboring pseudogene CYP2A7. Two studies found that CYP2A7 deletions were associated with ovarian cancer risk. Using their methodology, we aimed to characterize CYP2A6 SVs (which may be misidentified by prediction software as CYP2A7 SVs), then assess CYP2A6 SV-associated risk for ovarian cancer, and extend analyses to lung cancer.

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Associating CYP2A6 structural variants with ovarian and lung cancer risk in the UK Biobank: replication and extension - European Journal of Human Genetics

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Associating CYP2A6 structural variants with ovarian and lung cancer risk in the UK Biobank: replication and extension - European Journal of Human Genetics

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