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Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases - Nature Communications

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Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases - Nature Communications

Replicative DNA polymerases duplicate entire genomes at high fidelity. This feature is shared among the three domains of life and is facilitated by their dual polymerase and exonuclease activities. Family D replicative DNA polymerases (PolD), found exclusively in Archaea, contain an unusual RNA polymerase-like catalytic core, and a unique Mre11-like proofreading active site.

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Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases - Nature Communications

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Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases - Nature Communications

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