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Target-dependent RNA polymerase as universal platform for gene expression control in response to intracellular molecules - Nature Communications

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Target-dependent RNA polymerase as universal platform for gene expression control in response to intracellular molecules - Nature Communications

Controlling gene expression in response to specific molecules is an essential technique for regulating cellular functions. However, current platforms with transcription and translation regulators have a limited number of detectable molecules to induce gene expression. Here to address these issues, we present a Target-dependent RNA polymerase (TdRNAP) that can induce RNA transcription in response to the intracellular target specifically recognized by single antibody.

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Target-dependent RNA polymerase as universal platform for gene expression control in response to intracellular molecules - Nature Communications

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Target-dependent RNA polymerase as universal platform for gene expression control in response to intracellular molecules - Nature Communications

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