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Base-editing mutagenesis maps alleles to tune human T cell functions - Nature

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Base-editing mutagenesis maps alleles to tune human T cell functions - Nature

CRISPR-enabled screening is a powerful tool for the discovery of genes that control T cell function and has nominated candidate targets for immunotherapies1–6. However, new approaches are required to probe specific nucleotide sequences within key genes. Systematic mutagenesis in primary human T cells could reveal alleles that tune specific phenotypes. DNA base editors are powerful tools for introducing targeted mutations with high efficiency7,8.

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Base-editing mutagenesis maps alleles to tune human T cell functions - Nature

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Base-editing mutagenesis maps alleles to tune human T cell functions - Nature

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