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Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels - Acta Pharmacologica Sinica

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Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels - Acta Pharmacologica Sinica

Sigma-1 receptor (S1R) is a unique multi-tasking chaperone protein in the endoplasmic reticulum. Since S1R agonists exhibit potent antidepressant-like activity, S1R has become a novel target for antidepression therapy. With a rapid and sustained antidepressant effect, ketamine may also interact with S1R. In this study, we investigated whether the antidepressant action of ketamine was related to S1R activation.

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Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels - Acta Pharmacologica Sinica

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Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels - Acta Pharmacologica Sinica

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