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A multiple hits hypothesis for memory dysfunction in Parkinson disease - Nature Reviews Neurology

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A multiple hits hypothesis for memory dysfunction in Parkinson disease - Nature Reviews Neurology

Cognitive disorders are increasingly recognized in Parkinson disease (PD), even in early disease stages, and memory is one of the most affected cognitive domains. Classically, hippocampal cholinergic system dysfunction was associated with memory disorders, whereas nigrostriatal dopaminergic system impairment was considered responsible for executive deficits. Evidence from PD studies now supports involvement of the amygdala, which modulates emotional attribution to experiences.

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A multiple hits hypothesis for memory dysfunction in Parkinson disease - Nature Reviews Neurology

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A multiple hits hypothesis for memory dysfunction in Parkinson disease - Nature Reviews Neurology

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