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Conserved and divergent gene regulatory programs of the mammalian neocortex - Nature

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Conserved and divergent gene regulatory programs of the mammalian neocortex - Nature

Divergence of cis-regulatory elements drives species-specific traits1, but how this manifests in the evolution of the neocortex at the molecular and cellular level remains unclear. Here we investigated the gene regulatory programs in the primary motor cortex of human, macaque, marmoset and mouse using single-cell multiomics assays, generating gene expression, chromatin accessibility, DNA methylome and chromosomal conformation profiles from a total of over 200,000 cells.

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Conserved and divergent gene regulatory programs of the mammalian neocortex - Nature

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Conserved and divergent gene regulatory programs of the mammalian neocortex - Nature

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