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PTEN-restoration abrogates brain colonisation and perivascular niche invasion by melanoma cells - British Journal of Cancer

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PTEN-restoration abrogates brain colonisation and perivascular niche invasion by melanoma cells - British Journal of Cancer

Melanoma brain metastases (MBM) continue to be a significant clinical problem with limited treatment options. Highly invasive melanoma cells migrate along the vasculature and perivascular cells may contribute to residual disease and recurrence. PTEN loss and hyperactivation of AKT occur in MBM; however, a role for PTEN/AKT in perivascular invasion has not been described.

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PTEN-restoration abrogates brain colonisation and perivascular niche invasion by melanoma cells - British Journal of Cancer

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PTEN-restoration abrogates brain colonisation and perivascular niche invasion by melanoma cells - British Journal of Cancer

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