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Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM - Nature Chemical Biology

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Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM - Nature Chemical Biology

Compact Cas9 nucleases hold great promise for therapeutic applications. Although several compact Cas9 nucleases have been developed, many genomic loci still could not be edited due to a lack of protospacer adjacent motifs (PAMs). We previously developed a compact SlugCas9 recognizing an NNGG PAM. Here we demonstrate that SlugCas9 displays comparable activity to SpCas9. We developed a simple phage-assisted evolution to engineer SlugCas9 for unique PAM requirements.

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Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM - Nature Chemical Biology

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Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM - Nature Chemical Biology

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