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Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment - Nature Cell Biology

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Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment - Nature Cell Biology

Lineage transitions are a central feature of prostate development, tumourigenesis and treatment resistance. While epigenetic changes are well known to drive prostate lineage transitions, it remains unclear how upstream metabolic signalling contributes to the regulation of prostate epithelial identity. To fill this gap, we developed an approach to perform metabolomics on primary prostate epithelial cells.

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health cells lineage prostate treatment luminal differentiation metabolism antiandrogen

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Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment - Nature Cell Biology

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Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment - Nature Cell Biology

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