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Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations - Nature Reviews Immunology

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Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations - Nature Reviews Immunology

The approval of the first immune checkpoint inhibitors provided a paradigm shift for the treatment of malignancies across a broad range of indications. Whereas initially, single-agent immune checkpoint inhibition was used, increasing numbers of patients are now treated with combination immune checkpoint blockade, where non-redundant mechanisms of action of the individual agents generally lead to higher response rates.

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Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations - Nature Reviews Immunology

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Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations - Nature Reviews Immunology

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