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Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome - Nature Metabolism

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Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome - Nature Metabolism

Barth syndrome (BTHS) is a life-threatening genetic disorder with unknown pathogenicity caused by mutations in TAFAZZIN (TAZ) that affect remodeling of mitochondrial cardiolipin (CL). TAZ deficiency leads to accumulation of mono-lyso-CL (MLCL), which forms a peroxidase complex with cytochrome c (cyt c) capable of oxidizing polyunsaturated fatty acid-containing lipids.

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Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome - Nature Metabolism

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Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome - Nature Metabolism

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