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Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function - Nature Immunology

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Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function - Nature Immunology

Spleen marginal zone (MZ) B cells are important for antibody responses against blood-borne antigens. The signals they use to detect exposure to blood are not well defined. Here, using intravital two-photon microscopy in mice, we observe transient contacts between MZ B cells and red blood cells that are in flow. We show that MZ B cells use adhesion G-protein-coupled receptor ADGRE5 (CD97) for retention in the spleen.

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Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function - Nature Immunology

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Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function - Nature Immunology

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