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Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy - Nature Cancer

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Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy - Nature Cancer

Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested extensively for therapeutic vaccination in cancer, with mixed clinical results. Here, we present a cell-therapy platform based on mouse or human DC progenitors (DCPs) engineered to produce two immunostimulatory cytokines, IL-12 and FLT3L.

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Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy - Nature Cancer

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Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy - Nature Cancer

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