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5 months ago

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Endothelium directs fat remodeling in cachexia - Nature Cancer

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Endothelium directs fat remodeling in cachexia - Nature Cancer

Certain cancers disrupt metabolism, leading to the wasting syndrome known as cachexia. How tumor-induced mediators of cachexia induce changes in end organs is unclear. A study implicates the endothelium as an amplifier of tumor signals in fat, in which NOTCH1 promotes adipose tissue remodeling via retinoic acid, IL-33 and IGFBP3.

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Endothelium directs fat remodeling in cachexia - Nature Cancer

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Endothelium directs fat remodeling in cachexia - Nature Cancer

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