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Additivity predicts the efficacy of most approved combination therapies for advanced cancer - Nature Cancer

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Additivity predicts the efficacy of most approved combination therapies for advanced cancer - Nature Cancer

Most advanced cancers are treated with drug combinations. Rational design aims to identify synergistic combinations, but existing synergy metrics apply to preclinical, not clinical data. Here we propose a model of drug additivity for progression-free survival (PFS) to assess whether clinical efficacies of approved drug combinations are additive or synergistic. This model includes patient-to-patient variability in best single-drug response plus the weaker drug per patient.

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Additivity predicts the efficacy of most approved combination therapies for advanced cancer - Nature Cancer

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Additivity predicts the efficacy of most approved combination therapies for advanced cancer - Nature Cancer

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