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Tachycardia-induced metabolic rewiring as a driver of contractile dysfunction - Nature Biomedical Engineering

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Tachycardia-induced metabolic rewiring as a driver of contractile dysfunction - Nature Biomedical Engineering

Prolonged tachycardia—a risk factor for cardiovascular morbidity and mortality—can induce cardiomyopathy in the absence of structural disease in the heart. Here, by leveraging human patient data, a canine model of tachycardia and engineered heart tissue generated from human induced pluripotent stem cells, we show that metabolic rewiring during tachycardia drives contractile dysfunction by promoting tissue hypoxia, elevated glucose utilization and the suppression of oxidative phosphorylation.

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Tachycardia-induced metabolic rewiring as a driver of contractile dysfunction - Nature Biomedical Engineering

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Tachycardia-induced metabolic rewiring as a driver of contractile dysfunction - Nature Biomedical Engineering

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