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FOXP3 recognizes microsatellites and bridges DNA through multimerization - Nature

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FOXP3 recognizes microsatellites and bridges DNA through multimerization - Nature

FOXP3 is a transcription factor that is essential for the development of regulatory T cells, a branch of T cells that suppress excessive inflammation and autoimmunity1–5. However, the molecular mechanisms of FOXP3 remain unclear. Here we here show that FOXP3 uses the forkhead domain—a DNA-binding domain that is commonly thought to function as a monomer or dimer—to form a higher-order multimer after binding to TnG repeat microsatellites.

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FOXP3 recognizes microsatellites and bridges DNA through multimerization - Nature

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FOXP3 recognizes microsatellites and bridges DNA through multimerization - Nature

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