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Structural insights into intron catalysis and dynamics during splicing - Nature

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Structural insights into intron catalysis and dynamics during splicing - Nature

The group II intron ribonucleoprotein is an archetypal splicing system with numerous mechanistic parallels to the spliceosome, including excision of lariat introns1,2. Despite the importance of branching in RNA metabolism, structural understanding of this process has remained elusive. Here we present a comprehensive analysis of three single-particle cryogenic electron microscopy structures captured along the splicing pathway.

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Structural insights into intron catalysis and dynamics during splicing - Nature

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Structural insights into intron catalysis and dynamics during splicing - Nature

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