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Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome - Nature

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Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome - Nature

The canonical (caspase-1) and noncanonical (comprising caspases 4, 5 and 11; hereafter, caspase-4/5/11) inflammasomes both cleave gasdermin D (GSDMD) to induce pyroptosis1,2. Whereas caspase-1 processes IL-1β and IL-18 for maturation3–6, no cytokine target has been firmly established for lipopolysaccharide-activated caspase-4/5/117–9. Here we show that activated human caspase-4, but not mouse caspase-11, directly and efficiently processes IL-18 in vitro and during bacterial infections.

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Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome - Nature

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Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome - Nature

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