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tRNA therapeutics for genetic diseases - Nature Reviews Drug Discovery

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tRNA therapeutics for genetic diseases - Nature Reviews Drug Discovery

Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their therapeutic potential for the treatment of genetic diseases — primarily those associated with a mutation altering mRNA translation — has gained significant attention. Engineering tRNAs to readthrough nonsense mutation-associated premature termination of mRNA translation can restore protein synthesis and function.

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tRNA therapeutics for genetic diseases - Nature Reviews Drug Discovery

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tRNA therapeutics for genetic diseases - Nature Reviews Drug Discovery

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