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Targeting synapse function and loss for treatment of neurodegenerative diseases - Nature Reviews Drug Discovery

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Targeting synapse function and loss for treatment of neurodegenerative diseases - Nature Reviews Drug Discovery

Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or reverse synaptic damage remain elusive. In this Review, we discuss recent advances in understanding the molecular and cellular pathways that impair synapses in neurodegenerative diseases, including the effects of protein aggregation and neuroinflammation.

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Targeting synapse function and loss for treatment of neurodegenerative diseases - Nature Reviews Drug Discovery

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Targeting synapse function and loss for treatment of neurodegenerative diseases - Nature Reviews Drug Discovery

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