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A DNA nanodevice for mapping sodium at single-organelle resolution - Nature Biotechnology

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A DNA nanodevice for mapping sodium at single-organelle resolution - Nature Biotechnology

Cellular sodium ion (Na+) homeostasis is integral to organism physiology. Our current understanding of Na+ homeostasis is largely limited to Na+ transport at the plasma membrane. Organelles may also contribute to Na+ homeostasis; however, the direction of Na+ flow across organelle membranes is unknown because organellar Na+ cannot be imaged. Here we report a pH-independent, organelle-targetable, ratiometric probe that reports lumenal Na+.

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A DNA nanodevice for mapping sodium at single-organelle resolution - Nature Biotechnology

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A DNA nanodevice for mapping sodium at single-organelle resolution - Nature Biotechnology

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