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Tangles, not TANGO: targeting tau aggregates - Nature Aging

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Tangles, not TANGO: targeting tau aggregates - Nature Aging

Targeting tau in addition to amyloid-β could be the next phase of disease modification in Alzheimer's disease. The TANGO trial of gosuranemab, which binds the tau N terminus, affected neither clinical outcomes nor brain levels of aggregated tau. The results highlight the importance and challenge of reducing aggregated tau.

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Tangles, not TANGO: targeting tau aggregates - Nature Aging

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Tangles, not TANGO: targeting tau aggregates - Nature Aging

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