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In vivo reprogramming leads to premature death linked to hepatic and intestinal failure - Nature Aging
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The induction of cellular reprogramming via expression of the transcription factors Oct4, Sox2, Klf4 and c‐Myc (OSKM) can drive dedifferentiation of somatic cells and ameliorate age-associated phenotypes in multiple tissues and organs. However, the benefits of long-term in vivo reprogramming are limited by detrimental side‐effects.
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