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5 months ago

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Epithelial IFNγ signalling and compartmentalized antigen presentation orchestrate gut immunity - Nature

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Epithelial IFNγ signalling and compartmentalized antigen presentation orchestrate gut immunity - Nature

All nucleated cells express major histocompatibility complex I and interferon‐γ (IFNγ) receptor1, but an epithelial cell-specific function of IFNγ signalling or antigen presentation by means of major histocompatibility complex I has not been explored. We show here that on sensing IFNγ, colonic epithelial cells productively present pathogen and self-derived antigens to cognate intra-epithelial T cells, which are critically located at the epithelial barrier.

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Epithelial IFNγ signalling and compartmentalized antigen presentation orchestrate gut immunity - Nature

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Epithelial IFNγ signalling and compartmentalized antigen presentation orchestrate gut immunity - Nature

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