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Structural insights into cytokine cleavage by inflammatory caspase-4 - Nature

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Structural insights into cytokine cleavage by inflammatory caspase-4 - Nature

Inflammatory caspases are key enzymes in mammalian innate immunity that control the processing and release of interleukin-1 (IL-1)-family cytokines1,2. Despite the biological importance, the structural basis for inflammatory caspase-mediated cytokine processing has remained unclear. To date, catalytic cleavage of IL-1-family members, including pro-IL-1β and pro-IL-18, has been attributed primarily to caspase-1 activities within canonical inflammasomes3.

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Structural insights into cytokine cleavage by inflammatory caspase-4 - Nature

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Structural insights into cytokine cleavage by inflammatory caspase-4 - Nature

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