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AGO2 silences mobile transposons in the nucleus of quiescent cells - Nature Structural & Molecular Biology

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AGO2 silences mobile transposons in the nucleus of quiescent cells - Nature Structural & Molecular Biology

Argonaute 2 (AGO2) is a cytoplasmic component of the miRNA pathway, with essential roles in development and disease. Yet little is known about its regulation in vivo. Here we show that in quiescent mouse splenocytes, AGO2 localizes almost exclusively to the nucleus. AGO2 subcellular localization is modulated by the Pi3K–AKT–mTOR pathway, a well-established regulator of quiescence.

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AGO2 silences mobile transposons in the nucleus of quiescent cells - Nature Structural & Molecular Biology

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AGO2 silences mobile transposons in the nucleus of quiescent cells - Nature Structural & Molecular Biology

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