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TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy - Nature Neuroscience

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TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy - Nature Neuroscience

Transcription factor EB (TFEB) mediates gene expression through binding to the coordinated lysosome expression and regulation (CLEAR) sequence. TFEB targets include subunits of the vacuolar ATPase (v-ATPase), which are essential for lysosome acidification. Single-nucleus RNA sequencing of wild-type and PS19 (Tau) transgenic mice expressing the P301S mutant tau identified three unique microglia subclusters in Tau mice that were associated with heightened lysosome and immune pathway genes.

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TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy - Nature Neuroscience

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TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy - Nature Neuroscience

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