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Product analogue binding identifies the copper active site of particulate methane monooxygenase - Nature Catalysis

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Product analogue binding identifies the copper active site of particulate methane monooxygenase - Nature Catalysis

Nature's primary methane-oxidizing enzyme, the membrane-bound particulate methane monooxygenase (pMMO), catalyses the oxidation of methane to methanol. Copper is required for pMMO activity, and decades of structural and spectroscopic studies have sought to identify the active site among three candidates: the CuB, CuC and CuD sites.

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Product analogue binding identifies the copper active site of particulate methane monooxygenase - Nature Catalysis

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Product analogue binding identifies the copper active site of particulate methane monooxygenase - Nature Catalysis

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