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Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements - Nature

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Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements - Nature

In eukaryotes, repetitive DNA sequences are transcriptionally silenced through histone H3 lysine 9 trimethylation (H3K9me3). Loss of silencing of the repeat elements leads to genome instability and human diseases, including cancer and ageing1–3. Although the role of H3K9me3 in the establishment and maintenance of heterochromatin silencing has been extensively studied4–6, the pattern and mechanism that underlie the partitioning of parental H3K9me3 at replicating DNA strands are unknown.

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Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements - Nature

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