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Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance - Nature Chemical Biology

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Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance - Nature Chemical Biology

The efficacy of aminoglycoside antibiotics is waning due to the acquisition of diverse resistance mechanisms by bacteria. Among the most prevalent are aminoglycoside acetyltransferases (AACs) that inactivate the antibiotics through acetyl coenzyme A-mediated modification. Most AACs are members of the GCN5 superfamily of acyltransferases which lack conserved active site residues that participate in catalysis. ApmA is the first reported AAC belonging to the left-handed β-helix superfamily.

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Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance - Nature Chemical Biology

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Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance - Nature Chemical Biology

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