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Stepwise requirements for polymerases δ and θ in theta-mediated end joining - Nature

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Stepwise requirements for polymerases δ and θ in theta-mediated end joining - Nature

Timely repair of chromosomal double-strand breaks is required for genome integrity and cellular viability. The polymerase theta-mediated end joining pathway has an important role in resolving these breaks and is essential in cancers defective in other DNA repair pathways, thus making it an emerging therapeutic target1.

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Stepwise requirements for polymerases δ and θ in theta-mediated end joining - Nature

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Stepwise requirements for polymerases δ and θ in theta-mediated end joining - Nature

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