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Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice - Nature Metabolism

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Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice - Nature Metabolism

The development of single-molecule co-agonists for the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) is considered a breakthrough in the treatment of obesity and type 2 diabetes. But although GIPR–GLP-1R co-agonism decreases body weight with superior efficacy relative to GLP-1R agonism alone in preclinical1–3 and clinical studies4,5, the role of GIP in regulating energy metabolism remains enigmatic.

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Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice - Nature Metabolism

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Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice - Nature Metabolism

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