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Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila - Nature Metabolism

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Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila - Nature Metabolism

Glucose is the primary source of energy for the brain; however, it remains controversial whether, upon neuronal activation, glucose is primarily used by neurons for ATP production or if it is partially oxidized in astrocytes, as proposed by the astrocyte–neuron lactate shuttle model for glutamatergic neurons. Thus, an in vivo picture of glucose metabolism during cognitive processes is missing.

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Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila - Nature Metabolism

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Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila - Nature Metabolism

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