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m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration - Nature

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m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration - Nature

Microsatellite repeat expansions within genes contribute to a number of neurological diseases1,2. The accumulation of toxic proteins and RNA molecules with repetitive sequences, and/or sequestration of RNA-binding proteins by RNA molecules containing expanded repeats are thought to be important contributors to disease aetiology3–9. Here we reveal that the adenosine in CAG repeat RNA can be methylated to N1-methyladenosine (m1A) by TRMT61A, and that m1A can be demethylated by ALKBH3.

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m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration - Nature

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m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration - Nature

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