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Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma - Nature Genetics

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Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma - Nature Genetics

Circular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of oncogenic gene expression, evolution of drug resistance and poor patient outcomes. Applying computational methods for the detection and reconstruction of ecDNA across a retrospective cohort of 481 medulloblastoma tumors from 465 patients, we identify circular ecDNA in 82 patients (18%).

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Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma - Nature Genetics

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Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma - Nature Genetics

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