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Synthesis of dienes from pyrrolidines using skeletal modification - Nature Communications

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Synthesis of dienes from pyrrolidines using skeletal modification - Nature Communications

Saturated N-heterocyclic pyrrolidines are common in natural products, medicinal compounds and agrochemicals. However, reconstruction of their skeletal structures creating new chemical space is a challenging task, and limited methods exist for this purpose. In this study, we report a skeletal modification strategy for conversion of polar cyclic pyrrolidines into nonpolar linear dienes through a N-atom removal and deconstruction process.

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Synthesis of dienes from pyrrolidines using skeletal modification - Nature Communications

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Synthesis of dienes from pyrrolidines using skeletal modification - Nature Communications

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