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Checkpoint kinase 2 controls insulin secretion and glucose homeostasis - Nature Chemical Biology

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Checkpoint kinase 2 controls insulin secretion and glucose homeostasis - Nature Chemical Biology

After the discovery of insulin, a century ago, extensive work has been done to unravel the molecular network regulating insulin secretion. Here we performed a chemical screen and identified AZD7762, a compound that potentiates glucose-stimulated insulin secretion (GSIS) of a human β cell line, healthy and type 2 diabetic (T2D) human islets and primary cynomolgus macaque islets.

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Checkpoint kinase 2 controls insulin secretion and glucose homeostasis - Nature Chemical Biology

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Checkpoint kinase 2 controls insulin secretion and glucose homeostasis - Nature Chemical Biology

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